CODEX STAN 229 RECOMMENDED METHODS OF ANALYSIS FOR PESTICIDE RESIDUES
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3C3DA69CDBF54335B658008F11E6B43F |
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文件大小(MB)： |
0.09 |
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页数： |
35 |
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日期： |
2004-12-27 |
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CODEX STAN 229 Page 1 of 35,RECOMMENDED METHODS OF ANALYSIS FOR PESTICIDE RESIDUES,CODEX STAN 2291,1. INTRODUCTION,1.1 Scope,Hereunder are given analytical methods which can, from practical experience of the Working,Group on Methods of Analysis to the Codex Committee on Pesticide Residues, be applied to the,determination of pesticide residues for regulatory purposes. The list, given in par.2, is not exhaustive and,methods not mentioned in the list can also be applied, provided that they can be shown to be effective.,1.2 Criteria for the selection of analytical methods,Whenever possible, the Working Group used the following criteria when selecting analytical,methods:,(i) published in books, manuals or open literature; (For some newer compounds, few,methods might be available from these sources; in those cases, GIFAP is prepared to,supply analytical methods to regulatory authorities as a matter of routine policy and to,other scientists on a case by case basis. Requests can be directed to: GIFAP, Avenue,Albert Lancaster 79A, 1180 Brussels, Belgium);,(ii) collaboratively studied or known to have been validated in a large number of laboratories;,(iii) capable of determining more than one residue, i.e. multi-residue methods;,(iv) suitable for as many commodities as possible at or below the specified MRLs;,(v) applicable in a regulatory laboratory equipped with routine analytical instrumentation.,Preference was given to gas chromatography or high performance liquid chromatography as the,determinative step for the methods. Under certain conditions however, methods using less sophisticated,procedures, such as thin-layer chromatography or spectrophotometry, may be applicable. This may be the,case, for example, when an exporting country wants to check whether or not a commodity produced in,that country complies with an Codex MRL. In this case, the treatment history of the commodity may be,known or assumed, so that the method used need not be as elaborate as in cases where samples of,unknown treatment history are under investigation. Also, when the MRL is high compared to the limit of,determination, simpler methodology may be applied in order to arrive at a "pass/no pass" decision or for,quick screening purposes.,1.3 Application of methods,It will always be necessary for the analyst to validate a method before it is first applied in a,practical situation. There is a further need for regular checks on the performance of the method in use at,both the MRL and at the lower limit of determination. For all new pesticide/commodity combinations the,1 Last revised in 1993,CODEX STAN 229 Page 2 of 35,method must be validated following Good Practice in Residue Analysis, (see reference 4 ). Confirmation,of the identity of an indicated residue by an independent technique is also to be regarded as an essential,part of Good Practice in Residue Analysis, especially when the initial result suggests that an MRL is,exceeded. Mass spectrometry has become for many residues the method of choice for confimatory,purposes, but the ultimate choice of a confirmatory test depends upon the technique used in the initial,determination and upon the available instrumentation and necessary expertise.,1.4 References to literature,Other relevant Codex recommendations in the field of enforcement of Codex maximum limits for,pesticide residues are as follows:,1. Recommended Methods of Sampling for the Determination of Pesticide Residues (Ref:,Codex Alimentarius Vol. 2, Section 3 ).,2. Portion of a Commodities to which Codex Maximum Residue Limits apply and which should,be analysed (Ref: Codex Alimentarius Vol. 2, Section 4.1).,3. Explanatory Notes on Codex Maximum Limits for Pesticide Residues (Ref: Codex,Alimentarius Vol. 2, Section 1).,4. Codex Guidelines on Good Practice in Pesticide Residue Analysis. (Ref: Codex Alimentarius,Suppl 1 to vol, 2. Section 4).,In paragraph 3 references can be found to:,- general articles on pesticide residue methodology (paragraph 3.1);,- manuals (paragraph 3.2);,- individual papers (paragraph 3.3).,After each reference given in paragraph 3.3, the compounds to which the methods involved apply,are indicated by their CCPR-number.,CODEX STAN 229 Page 3 of 35,2. LIST OF METHODS OF ANALYSIS,The numbers refer to the manuals and books listed in paragraph 3.2, the names to the (first) author of,the papers listed in paragraph 3.3.,___________________________________________________________________________________,____,CCPR,number,Compound References,001 aldrin/dieldrin 1a, 1n, 1o, 1p, 2a, 2d, 2f, 3, 4 (XII-5, 6; S1-5, S8-10, S12, S19), 5, 7a,(5, 6), 7c (S8-10, S12, S19), 8a, 8b, 8c, 8d, 9a (M1, M12),……
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